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Ackles was born in Dallas, Texas, the son of Donna Joan (née Shaffer) and Alan Roger Ackles, an actor. Ackles has a brother, Joshua, who is three years older, and sister, Mackenzie, who is seven years younger. He is of English, Irish and Scottish ancestry. He had planned to study sports medicine at Texas Tech University and become a physical therapist but instead moved to Los Angeles to start his acting career.